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      Flexible and directional fibre optic ultrasound transmitters using photostable dyes

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          Abstract

          All-optical ultrasound transducers are well-suited for use in imaging during minimally invasive surgical procedures. This requires highly miniaturised and flexible devices. Here we present optical ultrasound transmitters for imaging applications based on modified optical fibre distal tips which allow for larger transmitter element sizes, whilst maintaining small diameter proximal optical fibre. Three optical ultrasound transmitter configurations were compared; a 400 µm core optical fibre, a 200 µm core optical fibre with a 400 µm core optical fibre distal tip, and a 200 µm core optical fibre with a 400 µm core capillary distal tip. All the transmitters used a polydimethylsiloxane-dye composite material for ultrasound generation. The material comprised a photostable infra-red absorbing dye to provide optical absorption for the ultrasound transduction. The generated ultrasound beam profile for the three transmitters was compared, demonstrating similar results, with lateral beam widths <1.7 mm at a depth of 10 mm. The composite material demonstrates a promising alternative to previously reported materials, generating ultrasound pressures exceeding 2 MPa, with corresponding bandwidths ca. 30 MHz. These highly flexible ultrasound transmitters can be readily incorporated into medical devices with small lateral dimensions.

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          Biomedical photoacoustic imaging

          Paul Beard (2011)
          Photoacoustic (PA) imaging, also called optoacoustic imaging, is a new biomedical imaging modality based on the use of laser-generated ultrasound that has emerged over the last decade. It is a hybrid modality, combining the high-contrast and spectroscopic-based specificity of optical imaging with the high spatial resolution of ultrasound imaging. In essence, a PA image can be regarded as an ultrasound image in which the contrast depends not on the mechanical and elastic properties of the tissue, but its optical properties, specifically optical absorption. As a consequence, it offers greater specificity than conventional ultrasound imaging with the ability to detect haemoglobin, lipids, water and other light-absorbing chomophores, but with greater penetration depth than purely optical imaging modalities that rely on ballistic photons. As well as visualizing anatomical structures such as the microvasculature, it can also provide functional information in the form of blood oxygenation, blood flow and temperature. All of this can be achieved over a wide range of length scales from micrometres to centimetres with scalable spatial resolution. These attributes lend PA imaging to a wide variety of applications in clinical medicine, preclinical research and basic biology for studying cancer, cardiovascular disease, abnormalities of the microcirculation and other conditions. With the emergence of a variety of truly compelling in vivo images obtained by a number of groups around the world in the last 2–3 years, the technique has come of age and the promise of PA imaging is now beginning to be realized. Recent highlights include the demonstration of whole-body small-animal imaging, the first demonstrations of molecular imaging, the introduction of new microscopy modes and the first steps towards clinical breast imaging being taken as well as a myriad of in vivo preclinical imaging studies. In this article, the underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
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            Ultrasensitive plano-concave optical microresonators for ultrasound sensing

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              • Article: found
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              Carbon-Nanotube Optoacoustic Lens for Focused Ultrasound Generation and High-Precision Targeted Therapy

              We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and elastomeric polymer is formed on concave lenses, and used as an efficient optoacoustic source due to the high optical absorption of the CNTs and rapid heat transfer to the polymer upon excitation by pulsed laser irradiation. The CNT-coated lenses can generate unprecedented optoacoustic pressures of >50 MPa in peak positive on a tight focal spot of 75 μm in lateral and 400 μm in axial widths. This pressure amplitude is remarkably high in this frequency regime, producing pronounced shock effects and non-thermal pulsed cavitation at the focal zone. We demonstrate that the optoacoustic lens can be used for micro-scale ultrasonic fragmentation of solid materials and a single-cell surgery in terms of removing the cells from substrates and neighboring cells.
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                Author and article information

                Journal
                OSA Contin
                OSA Contin
                OSAC
                Osa Continuum
                Optical Society of America
                2578-7519
                08 September 2021
                15 September 2021
                : 4
                : 9
                : 2488-2495
                Affiliations
                [1 ]Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK
                [2 ]Wellcome/ESPRC Centre for Interventional and Surgical Sciences, 43-45 Foley Street, London, W1W 7TY, UK
                [3 ]Department of Cardiovascular Medicine, Royal Free NHS Foundation Trust, London, UK
                Author notes
                Author information
                https://orcid.org/0000-0001-8657-0546
                https://orcid.org/0000-0002-1658-4421
                Article
                431444
                10.1364/OSAC.431444
                10575603
                37841369
                e19b9ab3-3776-4d9d-be26-cf95d594cfd7
                Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

                https://creativecommons.org/licenses/by/4.0/

                History
                : 17 May 2021
                : 09 August 2021
                : 11 August 2021
                Funding
                Funded by: Royal Academy of Engineering 10.13039/501100000287
                Award ID: RF\201819\18\125
                Funded by: UCLH Biomedical Research Centre 10.13039/501100012317
                Award ID: BRC559
                Funded by: Wellcome Trust 10.13039/100010269
                Award ID: 203145/Z/16/Z
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