Jiazhen Zheng: Role: Formal analysisRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Fengjuan Chen: Role: ConceptualizationRole: ResourcesRole: SupervisionRole: Writing – original draft
Keyi Wu: Role: Data curationRole: Formal analysisRole: SupervisionRole: Writing – review &
editing
Jiancheng Wang: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: SupervisionRole:
Writing – original draft
Furong Li: Role: Data curationRole: Formal analysisRole: Project administrationRole: SoftwareRole:
SupervisionRole: Writing – review & editing
Shan Huang: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: SupervisionRole:
Validation
Jianyun Lu: Role: Formal analysisRole: InvestigationRole: ResourcesRole: SupervisionRole: Writing
– review & editing
Jinghan Huang: Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: SoftwareRole: SupervisionRole:
Writing – review & editing
Huamin Liu: Role: SupervisionRole: ValidationRole: Writing – review & editing
Rui Zhou: Role: Data curationRole: Software
Zhiwei Huang: Role: Data curationRole: InvestigationRole: Supervision
Bingyao Meng: Role: InvestigationRole: ValidationRole: VisualizationRole: Writing – review & editing
Zelin Yuan:
ORCID: https://orcid.org/0000-0002-3373-7194
Role: InvestigationRole: SoftwareRole: Supervision
Xianbo Wu:
ORCID: https://orcid.org/0000-0002-2706-9599
Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
ResourcesRole: ValidationRole: Writing – review & editing
Eric HY Lau: Role: Editor
Journal ID (nlm-ta): PLoS Negl Trop Dis
Journal ID (iso-abbrev): PLoS Negl Trop Dis
Journal ID (publisher-id): plos
Title:
PLoS Neglected Tropical Diseases
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1935-2727
ISSN
(Electronic):
1935-2735
Publication date
(Electronic):
29
November
2021
Publication date Collection:
November
2021
Volume: 15
Issue: 11
Electronic Location Identifier: e0009997
Affiliations
[1
]
Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory
of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong,
China
[2
]
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China
[3
]
Department of Medical Administration, Guangzhou Eighth People’s Hospital, Guangzhou,
Guangdong, China
[4
]
Department of Intensive Care Unit, The Third Affiliated Hospital of Southern Medical
University, Guangzhou, Guangdong, China
[5
]
School of Medicine, Southern University of Science and Technology, Shenzhen, China
[6
]
P3 biosafety laboratory, School of Public Health (Guangdong Provincial Key Laboratory
of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong,
China
[7
]
Department of Infectious Disease Control and Prevention, Guangzhou Center for Disease
Control and Prevention, Guangzhou, Guangdong, China
[8
]
Department of Biostatistics, School of Public Health, Boston University, Boston, United
States of America
[9
]
Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory
of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong,
China
The University of Hong Kong, CHINA
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PNTD-D-21-01160
DOI: 10.1371/journal.pntd.0009997
PMC ID: 8659415
PubMed ID: 34843492
SO-VID: e4dd42df-daee-488f-b2fd-d7ef05606a71
Copyright © © 2021 Zheng et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 82173607
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2706-9599
Xianbo Wu
Funded by:
Guangdong Basic and Applied Basic Research Foundation
Award ID: 2021A1515011684
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2706-9599
Xianbo Wu
Funded by:
Open Project of the Guangdong Provincial Key Laboratory of Tropical Disease Research
Award ID: 2020B1212060042
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2706-9599
Xianbo Wu
Funded by:
Guangzhou Science and Technology Project
Award ID: 202102080597
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2706-9599
Xianbo Wu
This study was supported by the National Natural Science Foundation of China (82173607)
to XW, the Guangdong Basic and Applied Basic Research Foundation (2021A1515011684)
to XW, Open Project of the Guangdong Provincial Key Laboratory of Tropical Disease
Research (2020B1212060042) to XW and Guangzhou Science and Technology Project (202102080597)
to XW. The funder had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
H1N1
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Co-Infections
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Respiratory Infections
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Respiratory Disorders
Subject:
Respiratory Infections
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
Subject:
Respiratory Disorders
Subject:
Respiratory Infections
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Covid 19
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Influenza
Subject:
Research and Analysis Methods
Subject:
Research Design
Subject:
Clinical Research Design
Subject:
Adverse Events
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses