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Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery.

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      Abstract

      Low levels of brain-derived neurotrophic factor (BDNF) are linked to delayed neurological recovery, depression, and cognitive impairment following stroke. Supplementation with BDNF reverses these effects. Unfortunately, systemically administered BDNF in its native form has minimal therapeutic value due to its poor blood brain barrier permeability and short serum half-life. In this study, a novel nano-particle polyion complex formulation of BDNF (nano-BDNF) was administered to mice after experimental ischemic stroke.

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      Affiliations
      [1 ] Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA.
      [2 ] Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill,, Chapel Hill, NC 27599-7362, USA.
      [3 ] Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA.
      [4 ] Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA; Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA.
      [5 ] Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA. Electronic address: raverma@uchc.edu.
      Journal
      Pharmacol. Biochem. Behav.
      Pharmacology, biochemistry, and behavior
      Elsevier BV
      1873-5177
      0091-3057
      October 26 2016
      : 150-151
      27619636
      S0091-3057(16)30156-3
      10.1016/j.pbb.2016.09.003
      5145740
      NIHMS819029

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