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      Motor Cortex Response to Pleasant Odor Perception and Imagery: The Differential Role of Personality Dimensions and Imagery Ability

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          Abstract

          Background

          Neuroimaging studies have shown a complex pattern of brain activation during perception of a pleasant odor and during its olfactory imagery. To date, little is known regarding changes in motor cortex excitability during these tasks. Bergamot essential oil (BEO) is extensively used in perfumes and cosmetics for its pleasantness. Therefore, to further our understanding of the human sense of smell, this study aimed to investigate the effect of perception and imagery of a pleasant odor (BEO) on motor cortex using Transcranial magnetic stimulation (TMS).

          Materials and Methods

          We examined the primary motor cortex (M1) excitability during perception of a pleasant odor (BEO) or perception of odorless saline (experiment 1). Furthermore, we tested the effect of olfactory imagery (OI) of BEO on corticospinal excitability (experiment 2). The increase in motor evoked potential (MEP) amplitude was correlated with personality dimensions scores, pleasantness, vividness, and general imagery ability.

          Results

          The results indicate that the corticospinal excitability changed after both perception and imagery of a pleasant odor (BEO). The correlation analysis shows an association with neuroticism personality trait (experiment 1) and with general olfactory imagery ability (experiment 2).

          Conclusion

          Both perception of a pleasant odor and its olfactory imagery modulate motor cortex excitability. The enhanced brain activation is affected by specific individual characteristics. Overall, our findings provide physiological evidence for a complex interaction between the olfactory and motor systems.

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          Most cited references69

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          The assessment and analysis of handedness: The Edinburgh inventory

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            Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee

            These guidelines provide an up-date of previous IFCN report on “Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application” (Rossini et al., 1994). A new Committee, composed of international experts, some of whom were in the panel of the 1994 “Report”, was selected to produce a current state-of-the-art review of non-invasive stimulation both for clinical application and research in neuroscience. Since 1994, the international scientific community has seen a rapid increase in non-invasive brain stimulation in studying cognition, brain–behavior relationship and pathophysiology of various neurologic and psychiatric disorders. New paradigms of stimulation and new techniques have been developed. Furthermore, a large number of studies and clinical trials have demonstrated potential therapeutic applications of non-invasive brain stimulation, especially for TMS. Recent guidelines can be found in the literature covering specific aspects of non-invasive brain stimulation, such as safety (Rossi et al., 2009), methodology (Groppa et al., 2012) and therapeutic applications (Lefaucheur et al., 2014). This up-dated review covers theoretical, physiological and practical aspects of non-invasive stimulation of brain, spinal cord, nerve roots and peripheral nerves in the light of more updated knowledge, and include some recent extensions and developments.
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              Primate anterior cingulate cortex: where motor control, drive and cognition interface.

              T. Paus (2001)
              Controversy surrounds the function of the anterior cingulate cortex. Recent discussions about its role in behavioural control have centred on three main issues: its involvement in motor control, its proposed role in cognition and its relationship with the arousal/drive state of the organism. I argue that the overlap of these three domains is key to distinguishing the anterior cingulate cortex from other frontal regions, placing it in a unique position to translate intentions to actions.
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                Author and article information

                Contributors
                Journal
                Front Hum Neurosci
                Front Hum Neurosci
                Front. Hum. Neurosci.
                Frontiers in Human Neuroscience
                Frontiers Media S.A.
                1662-5161
                12 July 2022
                2022
                : 16
                : 943469
                Affiliations
                [1] 1Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Policlinico Universitario “G. Martino”, University of Messina , Messina, Italy
                [2] 2Department of Medical Sciences, Hackensack Meridian School of Medicine , Nutley, NJ, United States
                [3] 3Department of Neurology, Hackensack Meridian School of Medicine , Nutley, NJ, United States
                [4] 4Department of Art History and Archeology, Italian Academy for Advanced Studies, Columbia University , New York, NY, United States
                [5] 5Department of Pre-Clinical Sciences, New York College of Podiatric Medicine , New York, NY, United States
                Author notes

                Edited by: Mariagiovanna Cantone, ASP Caltanissetta, Italy

                Reviewed by: Giuseppe Lanza, University of Catania, Italy; George M. Opie, University of Adelaide, Australia

                *Correspondence: Fortunato Battaglia, fortunato.battaglia@ 123456hmhn.org

                This article was submitted to Brain Health and Clinical Neuroscience, a section of the journal Frontiers in Human Neuroscience

                Article
                10.3389/fnhum.2022.943469
                9314567
                35903786
                e941d5d0-dab4-4d78-8824-26af15345c73
                Copyright © 2022 Infortuna, Gualano, Freedberg, Patel, Sheikh, Muscatello, Bruno, Mento, Chusid, Han, Thomas and Battaglia.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 13 May 2022
                : 17 June 2022
                Page count
                Figures: 4, Tables: 1, Equations: 0, References: 69, Pages: 8, Words: 6751
                Categories
                Neuroscience
                Original Research

                Neurosciences
                corticospinal excitability,pleasant odor perception,odor imagery,personality traits,transcranial magnetic stimulation (tms)

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