Intraperitoneal adhesions are associated with considerable co‐morbidity and have large
financial and public health repercussions. They have secondary effects that include
chronic pelvic pain, dyspareunia, subfertility and bowel obstruction. In women with
adhesions, subsequent surgery is more difficult, often takes longer, and is associated
with a higher complication rate ( Broek 2013 ). The significant burden of adhesions
has led to the development of several anti‐adhesion agents, although there is disagreement
as to their relative effectiveness. To summarise evidence derived from Cochrane systematic
reviews on the clinical safety and effectiveness of solid agents, gel agents, liquid
agents and pharmacological agents, used as adjuvants to prevent formation of adhesions
after gynaecological pelvic surgery. The Cochrane Database of Systematic Reviews was
searched using the keyword 'adhesion' up to August 2014. The Cochrane information
management system was also searched for any titles or protocols of reviews in progress.
Two review authors independently extracted information from the reviews, with disagreements
being resolved by a third review author. The quality of the included reviews was described
in a narrative manner, and the AMSTAR tool was used to formally assess each review
included in this overview. The quality of evidence provided in the original reviews
was described using GRADE methods. We included two reviews, one with 18 studies comparing
solid agents (oxidised regenerated cellulose expanded polytetrafluoroethylene, sodium
hyaluronate and carboxymethylcellulose, and fibrin sheets) with control or with each
other. The other review included 29 studies which compared liquid agents (4% icodextrin,
32% dextran, crystalloids), gel agents (carboxymethylcellulose and polyethylene oxide,
polyethylene glycol gels, hyaluronic acid based gel, 0.5% ferric hyaluronate gel,
sodium hyaluronate spray) and pharmacological agents (gonadotrophin‐releasing hormone
agonist, reteplase plasminogen activator, N,O‐carboxymethyl chitosan, steroid agents,
intraperitoneal noxytioline, intraperitoneal heparin, systemic promethazine) with
control or each other. Both reviews met all of the criteria of the AMSTAR assessment.
The reviews included as outcomes both the primary outcomes of this overview (pelvic
pain, pregnancy, live birth rate and quality of life (QoL)) and our secondary outcomes
(adverse effects, presence or absence of adhesions at second–look laparoscopy (SLL)
and adhesion score). However, neither of the reviews identified any primary studies
of solid, gel or pharmacological agents that reported any of our primary outcomes.
The only studies in either review that reported any of our primary outcomes were studies
comparing liquid agents versus control (saline or Hartmann's solution), which reported
pelvic pain (two studies), live birth (two studies) and pregnancy (three studies).
An external source of funding was stated for 25 of the 47 studies across both reviews;
in 24 of these studies the funding was commercial. Solid agents (18 studies) None
of our primary outcomes were reported. Adverse events were reported as an outcome
by only 9 of the 18 studies. These reported no adverse events. Liquid agents (nine
studies) There was no evidence of a difference between liquid agents and control (saline
or Hartmann's solution) with respect to pelvic pain (odds ratio (OR) 0.65, 95% confidence
interval (CI) 0.37 to 1.14, 1 study, n = 286, moderate quality evidence), pregnancy
rate (OR 0.64, 95% CI 0.36 to 1.14, 3 studies, n = 310, moderate quality evidence)
or live birth rate (OR 0.67, 95% CI 0.29 to 1.58, 2 studies, n = 208, moderate quality
evidence). No studies of liquid agents reported QoL. Adverse events were not reported
as an outcome by any of the nine studies. Gel agents (seven studies) None of our primary
outcomes were reported. Adverse events were not reported as an outcome by any of the
seven studies. Pharmacological agents (seven studies) None of our primary outcomes
were reported. Adverse events were reported as an outcome by only one of the seven
primary studies. This study reported no evidence of difference in ectopic pregnancy
rates between intraperitoneal noxytioline and no treatment (OR 4.91, 95% CI 0.45 to
53.27, 1 study, n = 33, low quality evidence). There is insufficient evidence to allow
us to draw any conclusions about the effectiveness and safety of anti‐adhesion agents
in gynaecological surgery, due to the lack of data on pelvic pain, fertility outcomes,
quality of life or safety. A substantial proportion of research in this field has
been funded by private companies that manufacture these agents, and further high powered,
independent trials will be needed before definitive conclusions can be made. Agents
that prevent the development of abdominal adhesions following surgery: an overview
of Cochrane reviews Background Abdominal adhesions are web like structures that commonly
form following abdominal or pelvic surgery. They are a result of damage to the lining
of the abdomen and can cause multiple conditions such as chronic pelvic pain and infertility.
Many types of solid, liquid, gel and pharmacological agents have been developed which,
when applied during surgery, supposedly reduce the chance that adhesions will develop.
However, there has been considerable disagreement as to which agent is more effective.
We aimed to summarise the evidence from Cochrane Reviews regarding anti‐adhesion agents
in gynaecological surgery. Search results Our search up to 31 August 2014 identified
two Cochrane reviews. One focused on solid agents, while the other focused on liquid
and gel anti‐adhesion agents as well as drugs that may prevent adhesions from forming.
All reviews were high quality, though the quality of specific comparisons in each
review ranged from low to high as a result of the limitations of the original studies.
The characteristics of the women who underwent the trials were recorded poorly among
the trials. Overview of the effectiveness of different anti‐adhesion agents There
was no evidence of a difference between liquid agents compared to no treatment or
placebo on pelvic pain, pregnancy rates or live birth rates following surgery (moderate
quality of evidence). There were no studies that investigated other anti‐adhesion
agents in preventing pelvic pain or infertility directly. Adverse events were reported
as an outcome by only 10 of the 47 primary studies. These reported no adverse events.
An external source of funding was stated for 25 of the 47 studies across both reviews;
in 24 of these studies the funding was commercial. The lack of studies investigating
the effect of these agents on pelvic pain and fertility means that it is impossible
to judge whether the reduction in adhesions produced by these agents translates to
any benefit to the patient. Furthermore, the multiple different ways in which adhesions
were measured made it difficult to combine studies. A substantial proportion of research
in this field has been funded by private companies that manufacture these agents,
and further high powered, independent trials will be needed before definitive conclusions
can be made.