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The role of anti-Müllerian hormone in gonadal development
October 1998
October 1998
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Abstract
Anti-Müllerian (AMH), a member of the transforming growth factor beta produced by
immature Sertoli cells and, to a lesser degree, by granulosa cells from birth to the
end of reproductive life, does not affect gonadal determination but has a negative
effect upon gonadal development in both sexes. It blocks meiosis in fetal ovaries,
leading to loss of germ cells and subsequent fibrous degeneration, and inhibits the
transcription of aromatase and LH receptor. AMH also affects the development and function
of the adult testis by blocking the differentiation of mesenchymal into Leydig cells
and by independently decreasing the expression of steroidogenic enzymes.