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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
Yoon-Jae Cho
1 ,
Aviad Tsherniak ,
Pablo Tamayo ,
Sandro Santagata ,
Azra Ligon ,
Heidi Greulich ,
Rameen Berhoukim ,
Vladimir Amani ,
Liliana Goumnerova ,
Charles G Eberhart ,
Ching C Lau ,
James M Olson ,
Richard J Gilbertson ,
Amar Gajjar ,
Olivier Delattre ,
Marcel Kool ,
Keith Ligon ,
Matthew Meyerson ,
Jill P Mesirov ,
Scott L Pomeroy
Apr 10 2011
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Abstract
Medulloblastomas are heterogeneous tumors that collectively represent the most common malignant brain tumor in children. To understand the molecular characteristics underlying their heterogeneity and to identify whether such characteristics represent risk factors for patients with this disease, we performed an integrated genomic analysis of a large series of primary tumors.