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      Pharmacokinetics of meropenem in critically ill patients with acute renal failure treated by continuous hemodiafiltration.

      Antimicrobial Agents and Chemotherapy
      Acute Kidney Injury, metabolism, Adult, Aged, Critical Illness, Female, Hemodiafiltration, Humans, Male, Middle Aged, Thienamycins, pharmacokinetics

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          Abstract

          The pharmacokinetics of meropenem were studied in nine anuric critically ill patients treated by continuous venovenous hemodiafiltration. Peak levels after infusion of 1,000 mg over 30 min amounted to 103.2 +/- 45.9 microgram/ml, and trough levels at 12 h were 9.6 +/- 3.8 microgram/ml. A dosage of 1,000 mg of meropenem twice a day provides plasma drug levels covering intermediately susceptible microorganisms. Further reductions of the dosage might be appropriate for highly susceptible bacteria or when renal replacement therapies with lower clearances are applied.

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          Author and article information

          Journal
          9736574
          105844

          Chemistry
          Acute Kidney Injury,metabolism,Adult,Aged,Critical Illness,Female,Hemodiafiltration,Humans,Male,Middle Aged,Thienamycins,pharmacokinetics

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