For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
128
views
99
references
 Top references
cited by
375
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      972
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      YAP/TAZ upstream signals and downstream responses

      research-article
      Author(s): 1 , 1 , 1 , 2 , *
      Publication date (Electronic):
      Journal: Nature cell biology

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Cell behavior is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP/TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects of cell behavior, including proliferation, cell plasticity and stemness essential for tissue regeneration. Corruption of cell-environment interplay leads to aberrant YAP/TAZ activation that is instrumental for multiple diseases, including cancer.

          Related collections

          Most cited references99

          • Record: found
          • Abstract: found
          • Article: not found

          Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

          Fa-Xing Yu, Bin Zhao, Nattapon Panupinthu … (2012)
          The Hippo pathway is crucial in organ size control, and its dysregulation contributes to tumorigenesis. However, upstream signals that regulate the mammalian Hippo pathway have remained elusive. Here, we report that the Hippo pathway is regulated by G-protein-coupled receptor (GPCR) signaling. Serum-borne lysophosphatidic acid (LPA) and sphingosine 1-phosphophate (S1P) act through G12/13-coupled receptors to inhibit the Hippo pathway kinases Lats1/2, thereby activating YAP and TAZ transcription coactivators, which are oncoproteins repressed by Lats1/2. YAP and TAZ are involved in LPA-induced gene expression, cell migration, and proliferation. In contrast, stimulation of Gs-coupled receptors by glucagon or epinephrine activates Lats1/2 kinase activity, thereby inhibiting YAP function. Thus, GPCR signaling can either activate or inhibit the Hippo-YAP pathway depending on the coupled G protein. Our study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the Hippo-YAP pathway as a critical signaling branch downstream of GPCR. Copyright © 2012 Elsevier Inc. All rights reserved.
          Article 0 comments Cited 677 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression.

            Mina Bissell, William C. Hines (2011)
            Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.
            Article 0 comments Cited 562 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Local force and geometry sensing regulate cell functions.

              Viola Vogel, Michael Sheetz (2006)
              The shapes of eukaryotic cells and ultimately the organisms that they form are defined by cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of force or geometry is transduced into biochemical signals that result in cell responses even for complex mechanical parameters such as substrate rigidity and cell-level form. These responses regulate cell growth, differentiation, shape changes and cell death. Recent tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms.
              Article 0 comments Cited 562 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-journal-id): 100890575
                Journal ID (pubmed-jr-id): 21417
                Journal ID (nlm-ta): Nat Cell Biol
                Journal ID (iso-abbrev): Nat. Cell Biol.
                Title: Nature cell biology
                ISSN (Print): 1465-7392
                ISSN (Electronic): 1476-4679
                Publication date Nihms-submitted: 9 October 2018
                Publication date (Electronic): 26 July 2018
                Publication date (Print): August 2018
                Publication date PMC-release: 01 February 2019
                Volume: 20
                Issue: 8
                Pages: 888-899
                Affiliations
                [1 ]Department of Molecular Medicine (DMM), University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy
                [2 ]IFOM - the FIRC Institute of Molecular Oncology
                Author notes
                [* ]To whom correspondence should be addressed. Stefano Piccolo, Department of Molecular Medicine, viale Colombo 3, 35100 Padua, Italy, TEL 0039049 8276098, FAX 0039049 8276079, piccolo@ 123456bio.unipd.it
                Article
                Accession ID: PMC6186418 Pmcid ID: PMC6186418 Pmc-uid ID: 6186418 Manuscript ID: ems79996
                DOI: 10.1038/s41556-018-0142-z
                PMC ID: 6186418
                PubMed ID: 30050119
                SO-VID: 3bd6db58-4078-4f9c-a135-0e26f50e878c
                History
                Categories
                Subject: Article

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content972

                See all similar

                Cited by370

                See all cited by

                Most referenced authors2,256

                See all reference authors