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      Reduction of oxidative DNA-damage in humans by brussels sprouts.

      Anticarcinogenic Agents, therapeutic use, Antimutagenic Agents, Antioxidants, Brassica, DNA, drug effects, metabolism, DNA Damage, Deoxyguanosine, analogs & derivatives, urine, Diet, Humans, Male, Oxidation-Reduction, Vegetables

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          The effect of consumption of Brussels sprouts on levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in human urine was investigated in 10 healthy, male, non-smoking volunteers. Following a 3 week run-in period, five volunteers continued on a diet free of cruciferous vegetables for a subsequent 3 week intervention period (control group), while the other five (sprouts group) consumed 300 g of cooked Brussels sprouts per day, at the expense of 300 g of a glucosinolate-free vegetable. Levels of 8-oxodG in 24 h urine samples were measured by HPLC. In the control group there was no difference between the two periods in levels of 8-oxodG (P = 0.72). In contrast, in the sprouts group the levels of 8-oxodG were decreased by 28% during the intervention period (P = 0.039). The present findings support the results of epidemiologic studies that consumption of cruciferous vegetables may result in a decreased cancer risk.

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