Protein bio-corona: critical issue in immune nanotoxicology

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Abstract

With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein “bio-corona.” The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle’s physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.

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Most cited references 107

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Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts.

Martin Lundqvist, Johannes Stigler, Giuliano Elia … (2008)

Nanoparticles in a biological fluid (plasma, or otherwise) associate with a range of biopolymers, especially proteins, organized into the "protein corona" that is associated with the nanoparticle and continuously exchanging with the proteins in the environment. Methodologies to determine the corona and to understand its dependence on nanomaterial properties are likely to become important in bionanoscience. Here, we study the long-lived ("hard") protein corona formed from human plasma for a range of nanoparticles that differ in surface properties and size. Six different polystyrene nanoparticles were studied: three different surface chemistries (plain PS, carboxyl-modified, and amine-modified) and two sizes of each (50 and 100 nm), enabling us to perform systematic studies of the effect of surface properties and size on the detailed protein coronas. Proteins in the corona that are conserved and unique across the nanoparticle types were identified and classified according to the protein functional properties. Remarkably, both size and surface properties were found to play a very significant role in determining the nanoparticle coronas on the different particles of identical materials. We comment on the future need for scientific understanding, characterization, and possibly some additional emphasis on standards for the surfaces of nanoparticles.

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Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.

Chrisostomi Gialeli, Achilleas Theocharis, Nikos K Karamanos (2011)

Matrix metalloproteinases (MMPs) consist of a multigene family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as carcinogenesis. In this regard, their activity plays a pivotal role in tumor growth and the multistep processes of invasion and metastasis, including proteolytic degradation of ECM, alteration of the cell-cell and cell-ECM interactions, migration and angiogenesis. The underlying premise of the current minireview is that MMPs are able to proteolytically process substrates in the extracellular milieu and, in so doing, promote tumor progression. However, certain members of the MMP family exert contradicting roles at different stages during cancer progression, depending among other factors on the tumor stage, tumor site, enzyme localization and substrate profile. MMPs are therefore amenable to therapeutic intervention by synthetic and natural inhibitors, providing perspectives for future studies. Multiple therapeutic agents, called matrix metalloproteinase inhibitors (MMPIs) have been developed to target MMPs, attempting to control their enzymatic activity. Even though clinical trials with these compounds do not show the expected results in most cases, the field of MMPIs is ongoing. This minireview critically evaluates the role of MMPs in relation to cancer progression, and highlights the challenges, as well as future prospects, for the design, development and efficacy of MMPIs. © 2010 The Authors Journal compilation © 2010 FEBS.

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Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

Ronnie Fang, Che-Ming Hu, Brian T Luk … (2014)

Cell-derived nanoparticles have been garnering increased attention due to their ability to mimic many of the natural properties displayed by their source cells. This top-down engineering approach can be applied toward the development of novel therapeutic strategies owing to the unique interactions enabled through the retention of complex antigenic information. Herein, we report on the biological functionalization of polymeric nanoparticles with a layer of membrane coating derived from cancer cells. The resulting core–shell nanostructures, which carry the full array of cancer cell membrane antigens, offer a robust platform with applicability toward multiple modes of anticancer therapy. We demonstrate that by coupling the particles with an immunological adjuvant, the resulting formulation can be used to promote a tumor-specific immune response for use in vaccine applications. Moreover, we show that by taking advantage of the inherent homotypic binding phenomenon frequently observed among tumor cells the membrane functionalization allows for a unique cancer targeting strategy that can be utilized for drug delivery applications.

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Author and article information

Contributors

Aristidis Tsatsakis: aris@med.uoc.gr

Journal

Journal ID (nlm-ta): Arch Toxicol

Journal ID (iso-abbrev): Arch. Toxicol

Title: Archives of Toxicology

Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )

ISSN (Print): 0340-5761

ISSN (Electronic): 1432-0738

Publication date (Electronic): 20 July 2016

Publication date PMC-release: 20 July 2016

Publication date (Print): 2017

Volume: 91

Issue: 3

Pages: 1031-1048

Affiliations

[1 ]ISNI 0000 0004 0369 4968, GRID grid.433858.1, Immunology Department, , “Victor Babes” National Institute of Pathology, ; Bucharest, Romania

[2 ]ISNI 0000 0001 2322 497X, GRID grid.5100.4, Faculty of Biology, , University of Bucharest, ; Bucharest, Romania

[3 ]ISNI 0000 0004 0576 5395, GRID grid.11047.33, Laboratory of Biochemistry, Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Department of Chemistry, , University of Patras, ; Patras, Greece

[4 ]ISNI 0000 0004 0635 685X, GRID grid.4834.b, , Foundation for Research and Technology-Hellas (FORTH)/Institute of Chemical Engineering Sciences (ICE-HT), ; Patras, Greece

[5 ]ISNI 0000 0001 2294 473X, GRID grid.8536.8, Laboratório de Bioquímica e Biologia Cellular de Glicoconjugados, Programa de Glicobiologia, Instituto de Bioquímica Médica Leopoldo De Meis and Hospital Universitário Clementino Fraga Filho, , Universidade Federal do Rio de Janeiro, ; Rio de Janeiro, Brazil

[6 ]ISNI 0000 0001 2169 7132, GRID grid.25769.3f, Department of Toxicology, Faculty of Pharmacy, , Gazi University, ; Ankara, Turkey

[7 ]ISNI 0000 0004 0384 6757, GRID grid.413055.6, Department of Toxicology, , Faculty of Pharmacy University of Medicine and Pharmacy Craiova, ; Craiova, Romania

[8 ]ISNI 0000 0000 9828 7548, GRID grid.8194.4, Department of Toxicology, Faculty of Pharmacy, , “Carol Davila” University of Medicine and Pharmacy, ; Bucharest, Romania

[9 ]ISNI 0000 0004 0576 3437, GRID grid.8127.c, Laboratory of Anatomy-Histology-Embryology, Medical School, , University of Crete, ; Heraklion, Greece

[10 ]ISNI 0000 0004 0576 3437, GRID grid.8127.c, Department of Toxicology and Forensic Sciences, Medical School, , University of Crete, ; Heraklion, Greece

Article

Publisher ID: 1797

DOI: 10.1007/s00204-016-1797-5

PMC ID: 5316397

PubMed ID: 27438349

SO-VID: 2502d63c-2169-4d57-b168-b759ebd85722

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

History

Date received : 26 June 2016

Date accepted : 6 July 2016

Funding

Funded by: UEFISCDI

Award ID: PCE- ID-PCE-2011-3-0918

Award ID: PN-II-PT-PCCA-2013-4-1386

Award Recipient : Monica Neagu Carolina Constantin

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ScienceOpen disciplines: Toxicology

Keywords: bio-corona,nanoparticle,immunological identity

Data availability:

ScienceOpen disciplines: Toxicology

Keywords: bio-corona, nanoparticle, immunological identity

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Protein bio-corona: critical issue in immune nanotoxicology

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Journal of the Netherlands Society of Toxicology

Most cited references 107

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts.

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

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Cited by 56

Most referenced authors 2,695