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      Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.

      Cancer discovery

      immunology, Antigens, CD274, genetics, metabolism, Carcinoma, Non-Small-Cell Lung, Cell Line, Cytokines, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Transgenic, Oncogenes, Programmed Cell Death 1 Receptor, Receptor, Epidermal Growth Factor, Signal Transduction, T-Lymphocytes, Tumor Escape, Tumor Microenvironment, Animals

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          Abstract

          The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signature of immunosuppression manifested by upregulation of PD-1, PD-L1, CTL antigen-4 (CTLA-4), and multiple tumor-promoting inflammatory cytokines. We observed decreased CTLs and increased markers of T-cell exhaustion in mouse models of EGFR-driven lung cancer. PD-1 antibody blockade improved the survival of mice with EGFR-driven adenocarcinomas by enhancing effector T-cell function and lowering the levels of tumor-promoting cytokines. Expression of mutant EGFR in bronchial epithelial cells induced PD-L1, and PD-L1 expression was reduced by EGFR inhibitors in non-small cell lung cancer cell lines with activated EGFR. These data suggest that oncogenic EGFR signaling remodels the tumor microenvironment to trigger immune escape and mechanistically link treatment response to PD-1 inhibition. We show that autochthonous EGFR-driven lung tumors inhibit antitumor immunity by activating the PD-1/PD-L1 pathway to suppress T-cell function and increase levels of proinflammatory cytokines. These findings indicate that EGFR functions as an oncogene through non-cell-autonomous mechanisms and raise the possibility that other oncogenes may drive immune escape. ©2013 AACR.

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          Author and article information

          Journal
          10.1158/2159-8290.CD-13-0310
          24078774
          3864135

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