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      Algal Polysaccharides‐Based Nanoparticles for Targeted Drug Delivery Applications

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          Abstract

          A huge variety of polysaccharides can be obtained from algal biomass having several attractive properties such as cost‐effectiveness, non‐toxicity, biodegradability, abundant availability, and biocompatibility. In recent years, algal polysaccharides (including alginates, carrageenans, fucoidans, ulvans, and agaroses) have extensively been reported for their chemical properties and important bioactive potentialities. Furthermore, algal polysaccharides have gained huge scientific interest as they are a significant source of biologically active compounds, and they show various medical potentialities including anticancer, antiproliferative, anticoagulant, antitumoral, and antiviral properties. Exceptional physicochemical and biological characteristics make them interesting candidates for biotechnological and biomedical investigations. In this review, nanodrug delivery systems based on different algal‐polysaccharides (alginates, carrageenans, fucoidan, ulvan, and other) are described in a systematic way. Moreover, the current challenges and future prospects in the area of algal exploitation for biomedical applications are summarized at the end.

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          Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

          Polycyclic aromatic compounds (PACs) are known due to their mutagenic activity. Among them, 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA) are considered as two of the most potent mutagens found in atmospheric particles. In the present study 2-NBA, 3-NBA and selected PAHs and Nitro-PAHs were determined in fine particle samples (PM 2.5) collected in a bus station and an outdoor site. The fuel used by buses was a diesel-biodiesel (96:4) blend and light-duty vehicles run with any ethanol-to-gasoline proportion. The concentrations of 2-NBA and 3-NBA were, on average, under 14.8 µg g−1 and 4.39 µg g−1, respectively. In order to access the main sources and formation routes of these compounds, we performed ternary correlations and multivariate statistical analyses. The main sources for the studied compounds in the bus station were diesel/biodiesel exhaust followed by floor resuspension. In the coastal site, vehicular emission, photochemical formation and wood combustion were the main sources for 2-NBA and 3-NBA as well as the other PACs. Incremental lifetime cancer risk (ILCR) were calculated for both places, which presented low values, showing low cancer risk incidence although the ILCR values for the bus station were around 2.5 times higher than the ILCR from the coastal site.
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            Nano based drug delivery systems: recent developments and future prospects

            Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.
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              Alginate: properties and biomedical applications.

              Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications to date, as these gels retain structural similarity to the extracellular matrices in tissues and can be manipulated to play several critical roles. This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Starch - Stärke
                Starch Stärke
                Wiley
                0038-9056
                1521-379X
                July 2022
                May 12 2022
                July 2022
                : 74
                : 7-8
                Affiliations
                [1 ]School of Food Science and Technology Jiangsu Food and Pharmaceutical Science College Huaian 223003 China
                [2 ]State Key Laboratory of Bioreactor Engineering and School of Biotechnology East China University of Science and Technology Shanghai 200237 China
                [3 ]Department of Biochemistry Government College University Faisalabad 38000 Pakistan
                [4 ]Institute of Chemistry University of Sargodha Sargodha 40100 Pakistan
                [5 ]School of Biochemistry and Biotechnology University of Punjab Lahore 54590 Pakistan
                [6 ]School of Life Science and Food Engineering Huaiyin Institute of Technology Huaian 223003 China
                Article
                10.1002/star.202200014
                40636271-d87a-426b-9f63-3d34239c4479
                © 2022

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