Hirotaka Ata: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: ValidationRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Thomas L. Ekstrom:
ORCID: http://orcid.org/0000-0002-9363-2984
Role: Data curationRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Gabriel Martínez-Gálvez:
ORCID: http://orcid.org/0000-0002-4392-2596
Role: SoftwareRole: ValidationRole: Writing – original draftRole: Writing – review
& editing
Carla M. Mann: Role: SoftwareRole: ValidationRole: Writing – original draftRole: Writing – review
& editing
Alexey V. Dvornikov:
ORCID: http://orcid.org/0000-0003-1514-4747
Role: InvestigationRole: MethodologyRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Kyle J. Schaefbauer: Role: InvestigationRole: Writing – review & editing
Alvin C. Ma: Role: ConceptualizationRole: Data curationRole: InvestigationRole: Writing – review
& editing
Drena Dobbs: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Karl J. Clark:
ORCID: http://orcid.org/0000-0002-9637-0967
Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Stephen C. Ekker:
ORCID: http://orcid.org/0000-0003-0726-4212
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: Writing – original draftRole: Writing – review & editing
Shawn M. Burgess: Role: Editor
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
12
September
2018
Publication date Collection:
September
2018
Volume: 14
Issue: 9
Electronic Location Identifier: e1007652
Affiliations
[1
]
Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United
States of America
[2
]
Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States
of America
[3
]
Medical Scientist Training Program, Mayo Clinic, Rochester, MN, United States of America
[4
]
Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, United States
of America
[5
]
Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America
[6
]
Department of Health Technology and Informatics, The Hong Kong Polytechnic University,
Hong Kong, China
National Human Genome Research Institute (NIH), UNITED STATES
Author notes
The authors declare no competing interests exist.
Author information
Article
Publisher ID:
PGENETICS-D-18-00688
DOI: 10.1371/journal.pgen.1007652
PMC ID: 6152997
PubMed ID: 30208061
SO-VID: 5a21b73d-d69a-4232-9d30-0b6a636987ac
Copyright © © 2018 Ata et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000052, NIH Office of the Director;
Award ID: OD020166
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
Funded by: funder-id http://dx.doi.org/10.13039/100006108, National Center for Advancing Translational Sciences;
Award ID: UL1TR002377
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
Funded by: funder-id http://dx.doi.org/10.13039/100000057, National Institute of General Medical Sciences;
Award ID: GM63904
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
Funded by: funder-id http://dx.doi.org/10.13039/100000062, National Institute of Diabetes and Digestive and Kidney Diseases;
Award ID: P30DK090728
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
Funded by: American Heart Association (US)
Award ID: 16PRE30470004
Award Recipient
:
Hirotaka Ata
Funded by: funder-id http://dx.doi.org/10.13039/100007048, Mayo Foundation for Medical Education and Research;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
Funded by: Marriott Foundation
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
Funded by: funder-id http://dx.doi.org/10.13039/100000062, National Institute of Diabetes and Digestive and Kidney Diseases;
Award ID: P30DK84567
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0726-4212
Stephen C. Ekker
NIH OD020166; NIH UL1TR002377; NIH GM63904; P30DK090728; NIH P30DK84567; AHA 16PRE30470004;
Mayo MSTP; Mayo Foundation; and gift from Marriott Foundation. The funders had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
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Research Article
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Biology and life sciences
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Genetics
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DNA
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DNA repair
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Microhomology-Mediated End Joining
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Biology and life sciences
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Biochemistry
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Nucleic acids
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DNA
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DNA repair
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Microhomology-Mediated End Joining
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Model Organisms
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Animal Models
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Eukaryota
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Fish
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Osteichthyes
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Zebrafish
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Biology and Life Sciences
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Molecular Biology
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Molecular Biology Techniques
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Cloning
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Subcloning
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Research and Analysis Methods
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Molecular Biology Techniques
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Cloning
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Subcloning
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Genetic Loci
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Biotechnology
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Bioengineering
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Synthetic bioengineering
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Genome engineering
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Synthetic genome editing
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TALENs
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Engineering and technology
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Bioengineering
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Genome engineering
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Synthetic genome editing
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TALENs
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Biology and life sciences
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Synthetic biology
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Synthetic bioengineering
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Genome engineering
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Synthetic genome editing
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TALENs
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Engineering and technology
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Synthetic biology
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Synthetic bioengineering
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Genome engineering
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Synthetic genome editing
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TALENs
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Biology and life sciences
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Synthetic genomics
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Synthetic genome editing
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TALENs
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Engineering and technology
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Synthetic biology
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Synthetic genome editing
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TALENs
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Biology and life sciences
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Genetics
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DNA
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DNA repair
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Non-Homologous End Joining
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Biology and life sciences
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Biochemistry
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Nucleic acids
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DNA
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DNA repair
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Non-Homologous End Joining
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Biology and Life Sciences
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Molecular Biology
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Molecular Biology Techniques
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Artificial Gene Amplification and Extension
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Polymerase Chain Reaction
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Research and Analysis Methods
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Molecular Biology Techniques
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Artificial Gene Amplification and Extension
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Polymerase Chain Reaction
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Biology and life sciences
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Biochemistry
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Proteins
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DNA-binding proteins
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Nucleases
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Biology and Life Sciences
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Biochemistry
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Enzymology
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Enzymes
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Hydrolases
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Nucleases
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Biology and Life Sciences
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Biochemistry
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Proteins
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Enzymes
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Hydrolases
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Nucleases