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Abstract
Prenatal screening for Down syndrome has improved, but the number of resulting invasive
diagnostic procedures remains problematic. Measurement of circulating cell-free DNA
in maternal plasma might offer improvement.
[1
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Division of Medical Screening and Special Testing, Department of Pathology and Laboratory
Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence,
Rhode Island 02903, USA. gpalomaki@ipmms.org