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Abstract

Despite tremendous progress in basic and epidemiological research, effective prevention of most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but difficult prospect. However, new mouse models that recapitulate significant features of human cancer progression show that vaccines can keep precancerous lesions under control and might eventually be the spearhead of effective and reliable ways to prevent cancer.

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Cancer genes and the pathways they control.

Bert Vogelstein, Kenneth W. Kinzler (2004)

The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

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Cancer immunotherapy: moving beyond current vaccines.

Steven Rosenberg, James Yang, Nicholas Restifo (2004)

Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.

Shimon Sakaguchi (2005)

Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.

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Journal

PubMed ID:: 16498443

DOI:: 10.1038/nrc1815

ScienceOpen disciplines: Chemistry

Keywords: Cancer Vaccines,immunology,therapeutic use,Humans,Neoplasms,epidemiology,prevention & control

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ScienceOpen disciplines: Chemistry

Keywords: Cancer Vaccines, immunology, therapeutic use, Humans, Neoplasms, epidemiology, prevention & control

Vaccines for tumour prevention.

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Abstract

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Vaccines

Most cited references 86

Cancer genes and the pathways they control.

Cancer immunotherapy: moving beyond current vaccines.

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.

Author and article information

Journal

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