[1
]Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore,
MD, USA.
[2
]Welch Centre for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA.
[3
]Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular
Medicine, University of Edinburgh, Edinburgh, UK.
[4
]Department of Physiology, University of Maryland School of Medicine, Baltimore, MD,
USA.
[5
]Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical
Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg,
Germany.
[6
]Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig,
Leipzig, Germany.
[7
]LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
[8
]Target Sciences - Genetics, GlaxoSmithKline, Collegeville, PA, USA.
[9
]Smilow Center for Translational Research, Perelman School of Medicine, University
of Pennsylvania, Philadelphia, PA, USA.
[10
]Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
[11
]Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
[12
]Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore,
MD, USA.
[13
]Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt
Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public
Health, Vanderbilt University Medical Center, Nashville, TN, USA.
[14
]Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System
(626)/Vanderbilt University, Nashville, TN, USA.
[15
]deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
[16
]Department of Medicine, Division of Nephrology and Hypertension, University of Utah,
Salt Lake City, UT, USA.
[17
]Genetics, Merck & Co., Inc., Kenilworth, NJ, USA.
[18
]Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[19
]Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.
[20
]Institute of Genetics and Biophysics Adriano Buzzati-Traverso - CNR, Naples, Italy.
[21
]Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck),
Bolzano, Italy.
[22
]Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences
(IMS), Yokohama (Kanagawa), Japan.
[23
]Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University,
Fukuoka, Japan.
[24
]Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
[25
]Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
[26
]DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald,
Germany.
[27
]Department of Epidemiology, University of Groningen, University Medical Center Groningen,
Groningen, The Netherlands.
[28
]Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam,
The Netherlands.
[29
]Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public
Health, Imperial College London, London, UK.
[30
]Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar,
Pakistan.
[31
]Department of Neurobiology, Care Sciences and Society, Division of Family Medicine
and Primary Care, Karolinska Institutet, Stockholm, Sweden.
[32
]School of Health and Social Studies, Dalarna University, Falun, Sweden.
[33
]Department of Internal Medicine, Division of Nephrology, University of Groningen,
University Medical Center Groningen, Groningen, The Netherlands.
[34
]Division of Nephrology, University of Washington, Seattle, WA, USA.
[35
]Kidney Research Institute, University of Washington, Seattle, WA, USA.
[36
]Cardiology, Geneva University Hospitals, Geneva, Switzerland.
[37
]Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
[38
]Swiss Institute of Bioinformatics, Lausanne, Switzerland.
[39
]Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town,
South Africa.
[40
]Cardiovascular Health Research Unit, Department of Medicine, University of Washington,
Seattle, WA, USA.
[41
]Department of Biostatistics, University of Washington, Seattle, WA, USA.
[42
]Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
[43
]Human Genetics Centre, University of Texas Health Science Centre, Houston, Texas,
USA.
[44
]Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine
at Mount Sinai, New York, NY, USA.
[45
]University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste,
Italy.
[46
]Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University
of Leipzig, Leipzig, Germany.
[47
]Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg,
Regensburg, Germany.
[48
]Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular
Medicine, University of Edinburgh, Edinburgh, UK.
[49
]Centre for Global Health Research, Usher Institute of Population Health Sciences and
Informatics, University of Edinburgh, Edinburgh, UK.
[50
]Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville,
TN, USA
[51
]Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
[52
]Department of Cardiology, Ealing Hospital, Middlesex, UK.
[53
]Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
[54
]MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College
London, London, UK.
[55
]IRCCS Neuromed, Pozzilli, Italy.
[56
]Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne,
Switzerland.
[57
]Institute of Biomedical Technologies, Italy National Research Council, Segrate (Milano),
Italy.
[58
]Bio4Dreams - business nursery for life sciences, Bresso (Milano), Italy.
[59
]San Raffaele Research Institute, Milano, Italy.
[60
]Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The
Netherlands.
[61
]Section of Nephrology, Department of Internal Medicine, Leiden University Medical
Centre, Leiden, The Netherlands.
[62
]5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology,
Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
[63
]Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
[64
]Institute of Physiology, University of Zurich, Zurich, Switzerland.
[65
]Department of Women and Child Health, Hospital for Children and Adolescents, University
of Leipzig, Leipzig, Germany.
[66
]Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.
[67
]Department of Nephrology and Medical Intensive Care, Charité – Universitätsmedizin
Berlin, Germany.
[68
]Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg
(FAU), Germany.
[69
]Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald,
Germany.
[70
]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural
Research Program, National Institutes of Health, Baltimore, MD, USA.
[71
]Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University,
Uppsala, Sweden.
[72
]Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research
Centre for Environmental Health, Neuherberg, Germany.
[73
]Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for
Environmental Health, Neuherberg, Germany.
[74
]German Center for Diabetes Research (DZD), Neuherberg, Germany.
[75
]QIMR Berghofer Medical Research Institute, Brisbane, Australia.
[76
]Icelandic Heart Association, Kopavogur, Iceland.
[77
]Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik,
Iceland.
[78
]A list of members and affiliations appears in the
Supplementary Note.
[79
]Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
[80
]Montreal University Hospital Research Centre, CHUM, Montreal, QC, Canada.
[81
]Medpharmgene, Montreal, QC, Canada.
[82
]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural
Research Program, National Institutes of Health, Bethesda, MD, USA.
[83
]Clinical Division of Neurogeriatrics, Department of Neurology, Medical University
of Graz, Graz, Austria.
[84
]Institute for Medical Informatics, Statistics and Documentation, Medical University
of Graz, Graz, Austria.
[85
]Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics,
Chinese National Human Genome Centre, Shanghai, China.
[86
]Shanghai Industrial Technology Institute, Shanghai, China.
[87
]Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular
Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University,
Tampere, Finland.
[88
]Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University,
Tampere, Finland.
[89
]NHLBIs Framingham Heart Study, Framingham, MA, USA.
[90
]The Centre for Population Studies, NHLBI, Framingham, MA, USA.
[91
]Department of Physiology, University of Maryland School of Medicine
[92
]Department of Medicine, Division of Cardiovascular Medicine, Stanford University School
of Medicine, Stanford, CA, USA.
[93
]Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
[94
]Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences,
Uppsala University, Uppsala, Sweden.
[95
]Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
[96
]The Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland.
[97
]Landspitalinn University Hospital, Iceland.
[98
]University of Iceland, Iceland.
[99
]Geisinger Research, Biomedical and Translational Informatics Institute, Rockville,
MD, USA.
[100
]Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular
Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University,
Tampere, Finland.
[101
]Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University
Graduate School of Medicine, Kyoto, Japan.
[102
]Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
[103
]Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
[104
]DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance,
Munich, Germany.
[105
]Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany.
[106
]MRC-PHE Centre for Environment and Health, 323 School of Public Health, Imperial College
London, London, UK.
[107
]National Heart and Lung Institute, Imperial College London, London, UK.
[108
]Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig,
Leipzig, Germany.
[109
]Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical
Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
[110
]RIKEN Centre for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
[111
]Division of Biomedical Informatics and Personalized Medicine, School of Medicine,
University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
[112
]Nuffield Department of Population Health, Oxford University, Oxford, UK.
[113
]The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine
at Mount Sinai, New York, NY, USA.
[114
]The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount
Sinai, New York, NY, USA.
[115
]Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
[116
]Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford,
UK.
[117
]Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
[118
]Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University
of Graz, Graz, Austria.
[119
]Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The
University of Tokyo, Tokyo, Japan.
[120
]Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German
Research Centre for Environmental Health, Neuherberg, Germany.
[121
]Chair of Epidemiology Ludwig- Maximilians-Universität München at UNIKA-T Augsburg,
Augsburg, Germany.
[122
]Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
[123
]Institute of Human Genetics, Technische Universität München, Munich, Germany.
[124
]Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research
Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
[125
]VA Boston Healthcare System, Boston, MA, USA.
[126
]Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston,
MA, USA.
[127
]Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville,
TN, USA.
[128
]Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative
Studies Program, VA Boston Healthcare System, Boston, MA, USA.
[129
]Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
[130
]University of Queensland, St Lucia, Australia
[131
]Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden,
The Netherlands.
[132
]Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre
for Environmental Health, Neuherberg, Germany.
[133
]Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany.
[134
]Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University
(LMU) Munich, Munich, Germany.
[135
]Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount
Sinai, New York, NY, USA.
[136
]Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health,
Bethesda, MD, USA.
[137
]Data Tecnica International, Glen Echo, MD, USA.
[138
]Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald,
Greifswald, Germany.
[139
]Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
[140
]Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty
of Medicine and Health Technology, Tampere University, Tampere, Finland.
[141
]Department of Biostatistics, Boston University School of Public Health, Boston, MA,
USA.
[142
]Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University
Medical Centre, Leiden, The Netherlands.
[143
]University of Maryland School of Medicine, Baltimore, MD, USA.
[144
]Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
[145
]Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow,
UK.
[146
]Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University
School of Medicine, Boston, MA, USA.
[147
]Institute of Genetic and Biomedical Research, National Research Council of Italy,
UOS of Sassari, Li Punti (Sassari), Italy.
[148
]Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
[149
]Faculty of Medicine, University of Split, Split, Croatia.
[150
]Gen-info Ltd, Zagreb, Croatia.
[151
]Nephrology Service, Department of Specialties in Internal Medicine, University Hospitals
of Geneva, Geneva, Switzerland.
[152
]Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh,
UK.
[153
]Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical
Centre, Leiden, The Netherlands.
[154
]Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital,
Turku, Finland.
[155
]Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku,
Turku, Finland.
[156
]Centre for Population Health Research, University of Turku and Turku University Hospital,
Turku, Finland.
[157
]Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
[158
]Department of Health Sciences, University of Milan, Milano, Italy.
[159
]ePhood Scientific Unit, ePhood SRL, Milano, Italy.
[160
]Centre for Cardiovascular Prevention, First Faculty of Medicine, Department of Medicine,
Charles University in Prague, Prague, Czech Republic.
[161
]Thomayer Hospital, Prague, Czech Republic.
[162
]Department of Preventive Cardiology, Thomayer Hospital, Prague, Czech Republic.
[163
]Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of
Medicine, Baltimore, MD, USA.
[164
]Molecular Biology and Biochemistry, Gottfried Schatz Research Centre for Cell Signaling,
Metabolism and Aging, Medical University of Graz, Graz, Austria.
[165
]Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
[166
]Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical
University of Graz, Graz, Austria.
[167
]Division of Population Health and Genomics, Ninewells Hospital and Medical School,
University of Dundee, Dundee, UK.
[168
]Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig,
Germany.
[169
]Heart Centre Leipzig, Leipzig, Germany.
[170
]Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
[171
]CRCHUM, Montreal, QC, Canada.
[172
]Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam,
Rotterdam, The Netherlands.
[173
]Department of Cardiology, University of Groningen, University Medical Center Groningen,
Groningen, The Netherlands.
[174
]Department of Genetics, University of Groningen, University Medical Center Groningen,
Groningen, The Netherlands.
[175
]Durrer Centre for Cardiovascular Research, The Netherlands Heart Institute, Utrecht,
The Netherlands.
[176
]Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
[177
]Genomics plc, Oxford, UK.
[178
]Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald,
Greifswald, Germany.
[179
]Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne,
Switzerland.
[180
]Centre for Population Health Sciences, Usher Institute of Population Health Sciences
and Informatics, University of Edinburgh, Edinburgh, UK.
[181
]Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne,
Switzerland.
[182
]Department of Physiology and Biophysics, University of Mississippi Medical Centre,
Jackson, MS, USA.
[183
]Geisinger Research, Biomedical and Translational Informatics Institute, Danville,
PA, USA.
[184
]Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA.
[185
]Department of Nephrology, Geisinger, Danville, PA, USA.
[186
]Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes
and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
[187
]Department of Medicine, University of Maryland School of Medicine, Baltimore, MD,
USA.
[188
]Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology,
Department of Health Service, University of Washington, Seattle, WA, USA.
[189
]Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
[190
]Department of Nephrology and Rheumatology, Kliniken Südostbayern AG, Regensburg, Germany.
[191
]Department of Public Health and Primary Care, University of Cambridge, Cambridge,
UK.
[192
]Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences
(IMS), Osaka, Japan.
[193
]Department of Statistical Genetics, Osaka University Graduate School of Medicine,
Osaka, Japan.
[194
]Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt
University Medical Centre, Nashville, TN, USA.
[195
]Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt
University, Nashville, TN, USA.
[196
]These authors contributed equally to this work.
[197
]These authors jointly directed this project.