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Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models.
E F Murphy
1 ,
P D Cotter ,
S Healy ,
T M Marques ,
O O'Sullivan ,
F Fouhy ,
S F Clarke ,
P W O'Toole ,
E M Quigley ,
C Stanton ,
P R Ross ,
R M O'Doherty ,
F Shanahan
Dec 2010
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Abstract
Increased efficiency of energy harvest, due to alterations in the gut microbiota (increased Firmicutes and decreased Bacteroidetes), has been implicated in obesity in mice and humans. However, a causal relationship is unproven and contributory variables include diet, genetics and age. Therefore, we explored the effect of a high-fat (HF) diet and genetically determined obesity (ob/ob) for changes in microbiota and energy harvesting capacity over time.