Yongxin Mu: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ValidationRole: VisualizationRole: Writing
– original draft
Houzhi Yu:
ORCID: http://orcid.org/0000-0003-2973-6081
Role: InvestigationRole: MethodologyRole: Validation
Tongbin Wu:
ORCID: http://orcid.org/0000-0001-6232-3268
Role: Methodology
Jianlin Zhang: Role: Methodology
Sylvia M. Evans: Role: Formal analysisRole: Writing – review & editing
Ju Chen:
ORCID: http://orcid.org/0000-0001-7674-4776
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project
administrationRole: SupervisionRole: Writing – review & editing
Anthony B. Firulli: Role: Editor
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
6
April
2020
Publication date Collection:
April
2020
Volume: 16
Issue: 4
Electronic Location Identifier: e1008730
Affiliations
[1
]
Department of Medicine-Cardiology, University of California San Diego,Gilman Drive,
Mail Code, La Jolla, California, United States of America
[2
]
Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University,
Jinan, China
[3
]
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at
San Diego, La Jolla, CA, United States of America
Indiana University Purdue University at Indianapolis, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PGENETICS-D-20-00081
DOI: 10.1371/journal.pgen.1008730
PMC ID: 7182263
PubMed ID: 32251422
SO-VID: e6adb953-14d9-44d6-86d0-727e715668c8
Copyright © © 2020 Mu et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000009, Foundation for the National Institutes of Health;
Award ID: 1R01HL146759
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7674-4776
Ju Chen
JC is supported by grants R01HL146759, R01HL144872, and R01HL137957 from the National
Institutes of Health. SME is supported by grant R35HL144984 from the National Institutes
of Health. JC is the American Heart Association (AHA) Endowed Chair in Cardiovascular
Research. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Muscle Cells
Subject:
Cardiomyocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Cardiomyocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Muscle Tissue
Subject:
Muscle Cells
Subject:
Cardiomyocytes
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Embryology
Subject:
Embryos
Subject:
Research and Analysis Methods
Subject:
Specimen Preparation and Treatment
Subject:
Staining
Subject:
Immunostaining
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Organism Development
Subject:
Organogenesis
Subject:
Heart Development
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Coronary Arteries
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Coronary Arteries
Subject:
Medicine and Health Sciences
Subject:
Congenital Disorders
Subject:
Birth Defects
Subject:
Congenital Heart Defects
Subject:
Ventricular Septal Defects
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Morphogenesis
Subject:
Birth Defects
Subject:
Congenital Heart Defects
Subject:
Ventricular Septal Defects
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Congenital Heart Defects
Subject:
Ventricular Septal Defects