The aim of our study was to investigate the accuracy of 64-slice computed tomography (CT) for assessing haemodynamically significant stenoses of coronary arteries. CT angiography was performed in 67 patients (50 male, 17 female; mean age 60.1+/-10.5 years) with suspected coronary artery disease and compared with invasive coronary angiography. All vessels > or =1.5 mm were considered for the assessment of significant coronary artery stenosis (diameter reduction >50%). Forty-seven patients were identified as having significant coronary stenoses on invasive angiography with 18% (176/1005) affected segments. None of the coronary segments needed to be excluded from analysis. CT correctly identified all 20 patients having no significant stenosis on invasive angiography. Overall sensitivity for classifying stenoses was 94%, specificity was 97%, positive predictive value was 87%, and negative predictive value was 99%. Sixty-four-slice CT provides a high diagnostic accuracy in assessing coronary artery stenoses.
