Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression.

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Abstract

Focal segmental glomerulosclerosis (FSGS) is a common progressive chronic renal disease. Podocyte injury and loss are the postulated pivotal events that trigger FSGS. In this study, the authors aim to examine the evolution of FSGS in murine models histologically, ultrastructurally and immunohistochemically with special emphasis on podocytes and parietal epithelial cells (PECs).

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Journal

Journal ID (iso-abbrev): Ultrastruct Pathol

Title: Ultrastructural pathology

Publisher: Informa UK Limited

ISSN (Electronic): 1521-0758

ISSN (Print): 0191-3123

Publication date (Electronic): October 5 2018

Volume: 42

Issue: 5

Affiliations

[1 ] a Department of Pathology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.

[2 ] b Department of Family and Community Medicine , College of Medicine, University of Hail , Hail , Saudi Arabia.

[3 ] c Department of Physiology , College of Medicine, University of Hail , Hail , Saudi Arabia.

[4 ] d Department of Pharmacology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.

[5 ] e Intern , College of Medicine, King Faisal University , Riyadh , Saudi Arabia.

[6 ] f Department of Medicine and Nephrology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.

Article

DOI: 10.1080/01913123.2018.1501125

PubMed ID: 30285525

SO-VID: fa3c5723-a4f6-4837-bedc-9259464ec1e0

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Keywords: Electron microscopy,Focal segmental glomerulosclerosis,immunohistochemistry CD44 and WT-1,parietal epithelial cells,podocytes

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Keywords: Electron microscopy, Focal segmental glomerulosclerosis, immunohistochemistry CD44 and WT-1, parietal epithelial cells, podocytes

Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression.

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Electron Channelling Contrast Imaging (ECCI)

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