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      FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

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      Trends in Pharmacological Sciences

      Elsevier BV

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          Abstract

          Angiogenic growth factors such as fibroblast growth factors (FGFs) and vascular endothelial growth factors (VEGFs) are currently targets of intense efforts to inhibit deregulated blood vessel formation in diseases such as cancer. FGFs and VEGFs exert their effects via specific binding to cell surface-expressed receptors equipped with tyrosine kinase activity. Activation of the receptor kinase activity allows coupling to downstream signal transduction pathways that regulate proliferation, migration and differentiation of endothelial cells. Inhibitors of FGF and VEGF signalling are currently in clinical trials. In this article, the current knowledge of FGF- and VEGF-induced signal transduction that leads to specific biological responses will be summarized. Furthermore, the manner in which this knowledge is being exploited to regulate angiogenesis will be discussed.

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          Author and article information

          Journal
          Trends in Pharmacological Sciences
          Trends in Pharmacological Sciences
          Elsevier BV
          01656147
          April 2001
          April 2001
          : 22
          : 4
          : 201-207
          Article
          10.1016/S0165-6147(00)01676-X
          11282421
          © 2001

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