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Induction of anti-β2 -glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes.
G M A van Os
1 ,
J C M Meijers ,
Ç Agar ,
M V Seron ,
J A Marquart ,
P Åkesson ,
R T Urbanus ,
R H W M Derksen ,
H Herwald ,
M Mörgelin ,
P G D E Groot
Dec 2011
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Abstract
The antiphospholipid syndrome (APS) is characterized by the persistent presence of anti-β(2) -glycoprotein I (β(2) -GPI) autoantibodies. β(2) -GPI can exist in two conformations. In plasma it is a circular protein, whereas it adopts a fish-hook conformation after binding to phospholipids. Only the latter conformation is recognized by patient antibodies. β(2) -GPI has been shown to interact with Streptococcus pyogenes.