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      The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

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          Abstract

          The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.

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          MicroRNAs: target recognition and regulatory functions.

          David Bartel (2009)
          MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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            A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

            Leonardo Salmena, Laura Poliseno, Yvonne Tay … (2011)
            Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer. Copyright © 2011 Elsevier Inc. All rights reserved.
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              MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

              Rajesha Rupaimoole, Frank J Slack (2017)
              MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.
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                Author and article information

                Contributors
                Lucia Altucci: lucia.altucci@unicampania.it
                Carmela Dell’Aversana: carmela.dellaversana@cnr.it
                Journal
                Journal ID (nlm-ta): Clin Epigenetics
                Journal ID (iso-abbrev): Clin Epigenetics
                Title: Clinical Epigenetics
                Publisher: BioMed Central (London )
                ISSN (Print): 1868-7075
                ISSN (Electronic): 1868-7083
                Publication date (Electronic): 4 May 2023
                Publication date PMC-release: 4 May 2023
                Publication date Collection: 2023
                Volume: 15
                Electronic Location Identifier: 76
                Affiliations
                [1 ]GRID grid.411293.c, ISNI 0000 0004 1754 9702, Department of Precision Medicine, University of Campania ‘Luigi Vanvitelli’, Programma di Epigenetica Medica, , Azienda Ospedaliera Universitaria, ; Naples, Italy
                [2 ]GRID grid.39009.33, ISNI 0000 0001 0672 7022, Merck KGaA, ; 64293 Darmstadt, Germany
                [3 ]GRID grid.9841.4, ISNI 0000 0001 2200 8888, Outpatient Fertility Unit, , University of Campania ‘Luigi Vanvitelli’, ; 80138 Naples, Italy
                [4 ]Department of Obstetrics and Gynecology and Physiopathology of Human Reproduction, ASL Salerno, Salerno, Italy
                [5 ]GRID grid.9841.4, ISNI 0000 0001 2200 8888, Department of Woman, Child and General and Special Surgery, , University of Campania ‘Luigi Vanvitelli’, ; 80138 Naples, Italy
                [6 ]GRID grid.8158.4, ISNI 0000 0004 1757 1969, Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics “Giovanni Sichel”, , University of Catania, ; 95123 Catania, CT Italy
                [7 ]GRID grid.428067.f, ISNI 0000 0004 4674 1402, BIOGEM, ; Ariano Irpino, Italy
                [8 ]GRID grid.429047.c, ISNI 0000 0004 6477 0469, Institute of Experimental Endocrinology and Oncology ‘Gaetano Salvatore’ (IEOS)-National Research Council (CNR), ; Naples, Italy
                Article
                Publisher ID: 1490
                DOI: 10.1186/s13148-023-01490-0
                PMC ID: 10161563
                PubMed ID: 37143127
                SO-VID: 605a2800-07be-4f7a-907b-d7e2b4c56968
                Copyright © © The Author(s) 2023
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 28 February 2023
                Date accepted : 24 April 2023
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100009945, Merck KGaA;
                Award ID: EPigenomic in hYporesponderpatientS-EPYS Project
                Award ID: EPigenomic in hYporesponderpatientS-EPYS Project
                Award ID: EPigenomic in hYporesponderpatientS-EPYS Project
                Award ID: EPigenomic in hYporesponderpatientS-EPYS Project
                Award Recipient :
                Funded by: MISE
                Award ID: Nabucco Project
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100003407, Ministero dell’Istruzione, dell’Università e della Ricerca;
                Award ID: FISR2019_00374 MeDyCa-B84G19000200008
                Award Recipient :
                Categories
                Subject: Review
                Custom metadata
                issue-copyright-statement © The Author(s) 2023

                ScienceOpen disciplines: Genetics
                Keywords: epigenetics,fertility,ivf,reproduction
                Data availability:
                ScienceOpen disciplines: Genetics
                Keywords: epigenetics, fertility, ivf, reproduction

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