[1
]Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago,
IL USA
[2
]GRID grid.412807.8, ISNI 0000 0004 1936 9916, Division of Genetic Medicine, , Department of Medicine, Vanderbilt University Medical Center, ; Nashville, TN USA
[3
]GRID grid.152326.1, ISNI 0000 0001 2264 7217, Data Science Institute, Vanderbilt University, ; Nashville, TN USA
[4
]GRID grid.5335.0, ISNI 0000000121885934, Clare Hall, University of Cambridge, ; Cambridge, UK
[5
]GRID grid.5335.0, ISNI 0000000121885934, MRC Epidemiology Unit, University of Cambridge, ; Cambridge, UK
[6
]GRID grid.25879.31, ISNI 0000 0004 1936 8972, Department of Genetics, , University of Pennsylvania, Perelman School of Medicine, ; Philadelphia, PA USA
[7
]GRID grid.25879.31, ISNI 0000 0004 1936 8972, Department of Systems Pharmacology and Translational Therapeutics, , University of Pennsylvania, Perelman School of Medicine, ; Philadelphia, PA USA
[8
]GRID grid.419548.5, ISNI 0000 0000 9497 5095, Statistical Genetics, Max Planck Institute of Psychiatry, ; Munich, Germany
[9
]GRID grid.429884.b, ISNI 0000 0004 1791 0895, New York Genome Center, ; New York, NY USA
[10
]GRID grid.21729.3f, ISNI 0000000419368729, Department of Systems Biology, , Columbia University, ; New York, NY USA
[11
]GRID grid.170205.1, ISNI 0000 0004 1936 7822, Department of Human Genetics, , University of Chicago, ; Chicago, IL USA
[12
]GRID grid.66859.34, The Broad Institute of MIT and Harvard, ; Cambridge, MA USA
[13
]GRID grid.38142.3c, ISNI 000000041936754X, Department of Epidemiology, , Harvard T.H. Chan School of Public Health, ; Boston, MA USA
[14
]GRID grid.168010.e, ISNI 0000000419368956, Department of Biology, , Stanford University, ; Stanford, 94305 CA USA
[15
]GRID grid.38142.3c, ISNI 000000041936754X, Ocular Genomics Institute, Massachusetts Eye and Ear, Harvard Medical School, ; Boston, MA USA
[16
]GRID grid.152326.1, ISNI 0000 0001 2264 7217, Department of Biomedical Informatics, Department of Medicine, , Vanderbilt University, ; Nashville, TN USA
[17
]GRID grid.152326.1, ISNI 0000 0001 2264 7217, Center for Human Genetics Research, Department of Molecular Physiology and Biophysics,
Vanderbilt University School of Medicine, ; Nashville, TN USA
[18
]GRID grid.59734.3c, ISNI 0000 0001 0670 2351, Department of Genetics and Genomic Sciences, , Icahn School of Medicine at Mount Sinai, ; New York, NY USA
[19
]GRID grid.59734.3c, ISNI 0000 0001 0670 2351, Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai,
; New York, NY USA
[20
]GRID grid.59734.3c, ISNI 0000 0001 0670 2351, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine
at Mount Sinai, ; New York, NY USA
[21
]Université de Paris - EA 7537 BIOSTM, Paris, France
[22
]GRID grid.4991.5, ISNI 0000 0004 1936 8948, University of Oxford, ; Oxford, UK
[23
]GRID grid.168010.e, ISNI 0000000419368956, Department of Genetics, , Stanford University, ; Stanford, CA USA
[24
]GRID grid.168010.e, ISNI 0000000419368956, Department of Pathology, , Stanford University, ; Stanford, CA USA
[25
]GRID grid.214458.e, ISNI 0000000086837370, Department of Biostatistics, , University of Michigan, ; Ann Arbor, MI USA
License:
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,
which permits use, sharing, adaptation, distribution and reproduction in any medium
or format, as long as you give appropriate credit to the original author(s) and the
source, provide a link to the Creative Commons licence, and indicate if changes were
made. The images or other third party material in this article are included in the
article’s Creative Commons licence, unless indicated otherwise in a credit line to
the material. If material is not included in the article’s Creative Commons licence
and your intended use is not permitted by statutory regulation or exceeds the permitted
use, you will need to obtain permission directly from the copyright holder. To view
a copy of this licence, visit
http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (
http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a
credit line to the data.