Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

Practices in Wound Healing Studies of Plants

Read this article at

Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Various plant products have been used in treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Phytoconstituents derived from plants need to be identified and screened for antimicrobial activity for management of wounds. The in vitro assays are useful, quick, and relatively inexpensive. Small animals provide a multitude of model choices for various human wound conditions. The study must be conducted after obtaining approval of the Ethics Committee and according to the guidelines for care and use of animals. The prepared formulations of herbal extract can be evaluated by various physicopharmaceutical parameters. The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts.

      Related collections

      Most cited references 106

      • Record: found
      • Abstract: found
      • Article: not found

      Wound healing--aiming for perfect skin regeneration.

       Tamara Martin (1997)
      The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages. The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and contraction, as well as the growth factor and matrix signals present at a wound site, are now roughly understood. Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.
        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        A new approach to practical acute toxicity testing.

        A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is described. Using this, it is possible to obtain with 13 experimental animals adequate information on the acute toxicity and on the LD50. This method has no limitations and applies to drugs, agricultural and industrial chemicals. It can be used for every route of administration.
          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          Effect of silver on burn wound infection control and healing: review of the literature.

          Silver compounds have been exploited for their medicinal properties for centuries. At present, silver is reemerging as a viable treatment option for infections encountered in burns, open wounds, and chronic ulcers. The gold standard in topical burn treatment is silver sulfadiazine (Ag-SD), a useful antibacterial agent for burn wound treatment. Recent findings, however, indicate that the compound delays the wound-healing process and that silver may have serious cytotoxic activity on various host cells. The present review aims at examining all available evidence about effects, often contradictory, of silver on wound infection control and on wound healing trying to determine the practical therapeutic balance between antimicrobial activity and cellular toxicity. The ultimate goal remains the choice of a product with a superior profile of infection control over host cell cytotoxicity.
            Bookmark

            Author and article information

            Affiliations
            1Biochemical Research Laboratory, Centre for Scientific Research and Development, People's Group, Bhopal, Madhya Pradesh 462037, India
            2Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India
            Author notes
            Journal
            Evid Based Complement Alternat Med
            ECAM
            Evidence-based Complementary and Alternative Medicine : eCAM
            Hindawi Publishing Corporation
            1741-427X
            1741-4288
            2011
            26 May 2011
            26 May 2011
            : 2011
            3118986
            21716711
            10.1155/2011/438056
            Copyright © 2011 Rupesh Thakur et al.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            Categories
            Review Article

            Complementary & Alternative medicine

            Comments

            Comment on this article